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U-GEMMs

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Mice

hVEGFA(2)

Strain Name：C57BL/6Smoc-Vegfaem1(hVEGFA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-204984

The endogenous mice Vegfa gene was replaced by human VEGFA gene. While hVEGFA(Stock No.NM-HU-2000028) mice function similarly to hVEGFA(2) mice,for more detailed information please contact our technical advisor.

Mice

hSORT1

Strain Name：C57BL/6Smoc-Sort1em1(hSORT1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225035

The endogenous mouse Sort1 gene was replaced by human SORT1 gene.

Mice

hTLR9/hOX40

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4em3(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024

This TLR9 and OX40 double knockin strain is established by crossing TLR9-HU and OX40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hDDR1

Strain Name：C57BL/6Smoc-Ddr1tm1(hDDR1)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225086

The endogenous mouse Ddr1 gene was replaced by human DDR1 gene.

Mice

hPSGL-1

Strain Name：C57BL/6Smoc-Selplgem1(hSELPLG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00046

The endogenous mouse Selplg gene was replaced by human SELPLG gene.

Mice

Ctsk-2A-Cre

Strain Name：C57BL/6Smoc-Ctskem1(2A-Cre-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190019

The 2A-Cre-Wpre-polyA cassette is inserted before 3'UTR region of Ctsk gene.

Mice

Alb-DreERT2

Strain Name：C57BL/6Smoc-Albem1(Kozak-DreERT2-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200076

A Kozak-DreERT2-WPRE-pA expression cassette was knocked into the Alb gene start codon site.

Mice

hCD80

Strain Name：C57BL/6Smoc-Cd80em1(hCD80) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00074

The endogenous mouse Cd80 gene was replaced by human CD80 gene .

Mice

Il17a-Cre

Strain Name：C57BL/6Smoc-Il17aem1(iCre-polyA(SV40))Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200137

A iCre-polyA expression cassette was knocked into the Il17a gene start codon site. This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying autoimmune inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis.

Mice

Il11-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il11em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00036

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il11.

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