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U-GEMMs

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Mice

hCCR8/hCTLA-4

Strain Name：C57BL/6Smoc-Ccr8em1(hCCR8)Ctla4em1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210435

hCCR8(NM-HU-190053) was crossed with hCTLA4(NM-HU-00014) to generate hCCR8/hCTLA4 mice.

Mice

hOX40(2)

Strain Name：C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00078

The exon1-5 and partial exon6 of endogenous mouse Tnfrsf4(Ox40) gene was replaced by the corresponding region of human TNFRSF4(OX40) gene. While hOX40(Stock No.NM-HU-00041) mice function similarly to hOX40(2) mice,for more detailed information please contact our technical advisor.

Mice

hPD-1/hPD-L1/hOX40

Strain Name：C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00122

hPD-1(NM-HU-00015),hPD-L1(NM-HU-00062) were crossed with hOX40(NM-HU-00041) to generate hPD-1/hPD-L1/hOX40.

Mice

A2m-KO

Strain Name：C57BL/6Smoc-A2mem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190549

Exon 4 of A2m gene was deleted to generate A2m knockout mice.

Mice

Col1a1-TRE3G-dCas9-VPR-EGFP

Strain Name：C57BL/6Smoc-Col1a1em1(TRE3G-dCas9-VPR-eGFP-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00123

These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

Mice

Upk3a-2A-GFPCre

Strain Name：C57BL/6Smoc-Upk3aem1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210003

2A-EGFP-Cre expression cassette was knocked into the Upk3a gene .

Mice

hPD-1/hTIM3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00103

hPD-1(NM-HU-00015) was crossed with hTIM3(NM-HU-00054)to generate hPD-1/hTIM3 mice

Mice

NVG-hIL15

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocIl15em1(hIL15)Smoc
Strain State：Repository Live | Cat. NO.：GM-NVG-210001

The endogenous mice Il15 gene was replaced by human IL15 gene.

Mice

hIL1B

Strain Name：C57BL/6Smoc-Il1btm3(hIL1B)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190047

The endogenous mouse Il1b gene was replaced by human IL1B gene.

Mice

Ly6g-2A-DTRGFP(BALB/c)

Strain Name：BALB/cAnSmoc-Ly6gem(2A-DTRGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-204997

2A-DTRGFP expression cassette was knocked into the Ly6g gene .

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