Rag2-KO

Nomenclature

C57BL/6Smoc-Rag2em2Smoc

Cat. NO.

NM-KO-190429

Strain State

Repository Live

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Gene Summary

Gene Symbol
Rag2

Model Description

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.
Research Application:Immunodeficiency,tumor-bearing model

Disease Connection

Ulcerative Colitis
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive

Validation Data

FACS detection of T and B cells collected from Rag2 knockout mice

Figure 1. Loss of T,B cells in Rag2(-/-) mice.

Splenocytes and blood cells of Rag2 knockout mice were isolated. Fractions of T and B cells were characterized using flow-cytometry. 



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