U-GEMMs

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-IDH2(R172K)-IRES-Luciferase-2A-tdTomato)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-190076
Research Application:cancer research
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-c-MET-IRES-luciferase-2A-tdTomato)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-18052
Research Application:Tumor research; drug screening
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-MLL-AF9-IRES-Luciferase-2A-tdTomato -WPRE-polyA)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-190114
Research Application:Acute myelogenous leukemia model
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-hMSLN-IRES-Luciferase-WPRE-pA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-225094
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem(CAG-LSL-HA-hMYCN-IRES-BFP-Wpre-polyA)1Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-225000
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-NFE2L2(G81S)-IRES-Luciferase-2A-tdTomato)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-190077
Research Application:cancer research
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-NRF2-IRES-luciferase-2A-tdTomato)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-18050
Research Application:Tumor research; drug screening
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-PIK3CA(H1047R)-IRES-luciferase-2A-tdTomato)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-190065
Disease Connection:breast cancer, CLOVES syndrome, ovarian cancer, brain glioma
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem(CAG-LSL-hPLA2R1-IRES-EGFP)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-220264
Mice
Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-hPLAG1-IRES-Luciferase-2A-tdTomato-wpre-polyA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-215002
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