hMAPT
Nomenclature
C57BL/6Smoc-Mapttm1(hMAPT)Smoc
Cat. NO.
NM-HU-200116
Strain State
Repository Live
Gene Summary
Gene Symbol
Mapt
Model Description
Validation Data
Fig.1 Detection of MAPT expression in cerebellum by RT-PCR.
Wild type: only one band at 200 bp with primers F1/R1 (mMapt);
Homozygous: only one band at 181 bp with primers F2/R2 (hMAPT);
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig 2. Detection of mouse MAPT expression in Brain in hMAPT knockin mice by IHC.
Brains were collected from wild-type mice (+/+) and homozygous hMAPT mice (HO), and analyzed by IHC with anti-human MAPT antibody.
Abbr. HO/HO, homozygous; +/+, wild type.
Note. The anti-mouse MAPT Antibody cross-reacted with mouse MAPT and humanized MAPT.
Fig 3. Detection of human MAPT expression in Brain in hMAPT knockin mice by IHC.
Brains were collected from wild-type mice (+/+) and homozygous hMAPT mice (HO), and analyzed by IHC with anti-human MAPT antibody.
Abbr. HO/HO, homozygous; +/+, wild type.
Note. The anti-human MAPT Antibody cross-reacted with mouse MAPT and humanized MAPT.
Fig 4. Detection of human MAPT expression in Brain in hMAPT knockin mice by IF.
Brains were collected from wild-type mice (+/+) and homozygous hMAPT mice (HO), and analyzed by IF with anti-human MAPT antibody.
Abbr. HO/HO, homozygous; +/+, wild type.
Note. The anti-human MAPT Antibody cross-reacted with mouse MAPT and humanized MAPT.
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